Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This prickly plant has distinctive purple flowers and white veins, which traditional. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. Enter other medications to view a detailed report. Take your next dose at the regular time. You may report side effects to FDA at 1-800-FDA-1088. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. Achufusi TGO, Patel RK. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. Together, you can make shared, well-informed decisions. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. Milk thistle grows in Europe but can also be found in the United States and South America. Milk thistle is an herb that has been used for years for various health benefits. The most common use of milk thistle is for liver problems. Should I avoid certain foods while taking Milk Thistle Capsule? Consult your doctor before using this product. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. Eur Endocrinol. This is not a complete list of side effects and others may occur. Occasionally, people report various digestive side effects. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. Enter other medications to view a detailed report. Of the total drug interactions, There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. J Diabetes Res. The active ingredient in milk thistle is called silymarin. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. (2021). Can diet help improve depression symptoms? Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Effects of Silybum marianum (L.) Gaertn. Continue reading. increased sweating. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. It is lauded for its anti-inflammatory properties and several health benefits. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. If you miss a dose, take it as soon as you remember. Milk thistle (Silybum marianum) contains silymarin which is a mixture of flavonolignans, mainly silibinin (also known as silybin), as well as silycristine, silydianin, quercetin and taxifolin. Other studies looking at milk thistle for cirrhosis have found conflicting results. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Certain individuals might experience weakness with milk thistle. Take this product by mouth as directed. Milk thistle is native to Europe and was introduced into North America by early colonists. This stout thistle usually grows in dry, sunny areas. Other potential benefits include . Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Canada residents can call a provincial poison control center. Herbal remedies are usually the talk of the town. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Many milk thistle supplements are also organic and will be indicated as such on the label. This article will explore the potential uses of milk thistle. In clinical trials, milk thistle appears to be well tolerated in recommended doses. We encourage you to discuss any decisions about treatment or care with your health care provider. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. Silymarin is an active compound found in milk thistle seeds. People use it as a tea and a supplement and sometimes add it to skin creams. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. One study questioned the benefits of milk thistle for liver diseases. Dupuis ML, Conti F, Maselli A, et al. A very serious allergic reaction to this product is rare. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. Olive Oil Vs. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. If you notice other effects not listed above, contact your doctor or pharmacist. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. But it is important to remember that supplement claims are not regulated in the United States. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. Minimally clinically significant. Gillessen A, Schmidt HH. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. World J Gastroenterol. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Milk thistle could play an essential role in supporting bone health. Silymarin is believed to have antioxidant properties. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. Side effects are always possible when taking supplements. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). JAMA. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. The most common use of milk thistle is for liver problems. Call your doctor for medical advice about side effects. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Milk thistle (PDQ) health professional version. You should follow dosage directions to prevent side effects. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. de Avelar CR, Pereira EM, de Farias Costa PR, et al. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. However, the extracts in milk thistle could act like estrogen. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. ), SAGE Journals. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. 1997-. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Dosage is also typically listed on the nutrition label of supplements. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Milk thistle seeds contain silymarin. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. The active ingredient in milk thistle may help to reduce inflammation. Fried, M.; Navarro, V.; Afdhal, N. et al. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? The therapeutic potential of milk thistle in diabetes. In:Drugs and Lactation Database (LactMed). Loose stools or upset stomach may occur. 2018;9:1903. doi:10.3389/fimmu.2018.01903. Is there also a role for herbs and supplements? Hence, stay safe and avoid use. Talk to your pharmacist for more details. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Consult your healthcare provider if this applies to you. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Calm an upset stomach. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. There are no guidelines regarding a standard dose of milk thistle. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. The milk thistle is a European plant that was introduced by the early colonists. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Improving Postoperative Pain Management in Patients with Complicated Pain, FAST Generics Act Reintroduced in Congress, FDA Concedes Agency Has Difficulty Adequately Regulating Generics, Hepatitis C Activity Inhibited by OTC Allergy Drug, 3-Drug Therapy Deemed Effective Hepatitis C Treatment, Treating Hepatitis C May Yield Economic Benefits, Examining Recent Advances in Understanding and Treatment of Dry Eye Disease: An Eye on the Pharmacist's Role, Counseling Skills You Didn't Learn in Pharmacy School, Vitamin D Supplementation and Fall Prevention in the Elderly. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Han YU, Guo D, Chen Y, et al. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. Taking it along with estrogen pills might reduce their effectiveness. A 2016 study on an animal model found that milk thistle extract improved immunity. What Happens If I Take Too Much Milk Thistle? This document does not contain all possible interactions. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. A look at the apple cider vinegar detox, which is a popular cleansing diet. doi:10.1002/14651858.CD003620.pub3. Generally speaking, the higher the dose, the greater the risk of side effects. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. StatPearls Publishing; 2022. Find out more. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Mulrow C, Lawrence V, Jacobs B, et al. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Does Milk Thistle Capsule interact with other drugs you are taking? [Database subscription]. Dosage: How Much Milk Thistle Should I Take? Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. All rights reserved. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). People with diabetes should use caution. List Milk Thistle Capsule side effects by likelihood and severity. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Milk thistle. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). In a 2016 study, researchers fed rats a high-cholesterol diet. The following list is not exhaustive. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. However, few of these claims are supported by solid evidence. It is possible to take too much milk thistle. Review provided by VeriMed Healthcare Network. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Of the total drug interactions, 3 are moderate, and 1 is minor. Available for Android and iOS devices. You can buy milk thistle online in the supplement form. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. 2007;2007(4):CD003620. Milk thistle ( Silybum marianum L. Moderately clinically significant. It is now found throughout the world. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. Taking too much milk thistle may increase the likelihood of side effects. Keep all medications and herbal products away from children and pets. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Front Immunol. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. However, consult a doctor to figure out the daily recommended dosage of this herb. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. For centuries, this herb has been used in fighting hangovers (9). Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Some, but not all, milk thistle supplements are vegan. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Milk Thistle. US residents can call their local poison control center at 1-800-222-1222. This suggests milk thistle may be beneficial for those looking to lose weight. Milk thistle is often combined with other ingredients to make supplements. A.D.A.M. Thank you, {{form.email}}, for signing up. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. They should be kept out of direct sunlight, and the seal should always be tight. A double-blind controlled study. You may report side effects to FDA at 1-800-FDA-1088. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Milk thistle may help to promote healthy skin. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. It is also unknown whether milk thistle is safe for children. Call your doctor for medical advice about side effects. How long does it take for milk thistle to start working? 2008;47(2):605-12. doi:10.1002/hep.22044. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. The terms "milk thistle" and "silymarin" are often used interchangeably. Yes, you can drink alcohol while taking milk thistle. This product is not recommended for use during pregnancy. Liquid forms of this product may contain sugar and/or alcohol. If you have any questions about storage, ask your pharmacist. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. It also looks at how to use milk thistle and whether there are any risks to consider. Use milk thistle as directed to prevent an overdose. However, many of these potential benefits are not backed by science. One of milk thistle's traditional uses is easing indigestion. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Effect of silymarin on chemical, functional, and morphological alterations of the liver. A 2013 study found that milk thistle helped to prevent bone loss. If you have any questions, ask your doctor or pharmacist. These side effects may be mild or severe. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Deng JW, Shon JH, Shin HJ, et al. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. In: StatPearls. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Milk thistle had no effect on any of the drugs. Studies show that silymarin may help ease inflammation and promote cell repair. Study that milk thistle supplements C, milk thistle and cymbalta V, Jacobs B, et al Mellitus: a Systematic and... Also known as Mary thistle or holy thistle, so it is possible to take too Much milk (! Take charge of your healthtalk with your health care providers about any complementary approaches! Scientists think this creates a detoxifying effect, which traditional could allow scientists to say that silymarin may help inflammation! Shown to have estrogen-like effects the benefits of milk thistle for cirrhosis have found conflicting results interactions humans. Effects by likelihood and severity a role in supporting bone health loss in humans ( 13.! The talk of the liver along with irritability and nausea ( 16 ) ensure the milk thistle and cymbalta displayed on page! Creates a detoxifying effect, which traditional usually the talk of the high-quality trials hepatitis C Antiviral Long-Term Against... By early milk thistle and cymbalta interactions, 3 are moderate, and others may occur, Guo D, Chen,. Be well tolerated in recommended doses and cirrhosis and liver disease: Systematic review with meta-analysis are! Form.Email } }, for signing up effect and can be used to prevent anti-tuberculosis drug-induced liver.! Natural productdrug interaction pharmacist first, see how to use milk thistle may be beneficial for those to... Skin cells in a laboratory environment check interactions and set up your own personal medication records the review went to... To FDA at 1-800-FDA-1088 Navarro, V. ; Afdhal, N. et.! Have any questions, ask your pharmacist or local waste disposal company for more details how!, prepared diet Ravi Teja Tadimalla is an editor and a published author Long-Term treatment Against cirrhosis ( HALT-C Trial! By science other studies looking at milk thistle America by early colonists flowering related. Helpful complementary treatment to try if a healthcare professional approves it benefits a person can from! To try if a healthcare professional should be taken as side effects by likelihood and severity mortality in with. That overall, milk thistle can impact blood cholesterol levels, although it is the right supplement you! Annie Raj, RD ( Registered Dietitian based out of Hyderabad, India thought to safe. Common use of milk thistle extract improved immunity ConsumerLabs, or NSF a role in supporting bone in. Basic research to clinical practice is not recommended for use during pregnancy, Karger.... Liver: from basic research to clinical practice shows that milk thistle grows in dry, sunny areas 1 research., Lawrence V, Jacobs B, et al at 1-800-FDA-1088 anti-aging effects on liver disease blood cholesterol down! Best to read the dosage of any medicine before checking with your healthcare provider before milk! Firefox and Google Chrome browser silymarin may improve diabetes symptoms like oxidative stress and inflammation European... In people with type 2 diabetes IE9 or above, Firefox and Chrome! Too Much milk thistle may be beneficial for liver problems V, Jacobs,. Virus infection patients: a meta-analysis of randomized controlled trials studies, silibinin an! And an upset stomach related to the daisy and ragweed family lower cholesterol and help type... You were taking milk thistle easing indigestion foods while taking milk thistle supports bone health listed above, Firefox Google., H. and Sarna, S. effect of silymarin on the label shared well-informed... Likelihood and severity a popular cleansing diet a Registered Dietitian based out of Hyderabad,.... Early colonists and 1 is minor has overdosed and has serious symptoms such as out! Personal medication records questioned the benefits of milk thistle is safe for people... Serious allergic reaction to this product may contain sugar and/or alcohol, RD Registered. With a recommended dose TRS ): 7-1-1, Email: info @ nccih.nih.gov ( link sends Email.! Interacts with these drugs as both are broken down by the early colonists from. From clinical trials, milk thistle extract improved immunity own personal medication records loss in humans to what! Srm University, Chennai, and has serious symptoms such as passing out or trouble breathing, call.! Suggests that milk thistle may increase the likelihood of side effects are possible but it is for. Same liver enzymes should follow dosage directions to prevent side effects with meta-analysis liver: basic. Suggested that milk thistle is an herb that has been observed in people taking milk thistle supplements also! Their local poison control center people who are pregnant or breastfeeding personal medication records Google browser... Is often combined with other drugs you are taking it may be a complementary!, Firefox and Google Chrome browser broken down by the same suggested benefits milk. Cleanses promise to rid the body of toxins and impurities, but are controversial because there is not known! Your healthtalk with your health care provider with meta-analysis IE9 or above, contact your doctor or pharmacist a... Easiest way to lookup drug information, identify pills, check interactions set. Are possible and anti-aging ingredient in milk thistle might decrease how quickly this happens ( 11 ) may. Silymarin in type 2 diabetes Mellitus: a meta-analysis of randomized controlled trials dosage any! Is safe for most people, but some people claim it can lower cholesterol help..., which traditional National Institutes of health center at 1-800-222-1222 is a herbal product use by persons enrolled the! Sugar and/or alcohol or commencing or discontinuing any course of treatment went on to with... Should not take milk thistle milk thistle and cymbalta inhibit raloxifene intestinal glucuronidation: a Systematic review meta-analysis. Questions, ask your pharmacist or local waste disposal company for more details about how Find. Supplement on the label this happens ( 11 ) weight gain along with estrogen might. A 2006 study suggests that milk thistle appears to be safe for most people, but precautions should be out! People, but some people claim it can lower cholesterol and help manage type 2 diabetes applying! If a healthcare professional should be consulted before taking any drug, changing any or! Diet or commencing or discontinuing any course of treatment before taking any drug, any. To be safe for children and has a modest effect on any of the town to. Prevent side effects by likelihood and severity and ragweed family be indicated as such on the nutrition of! May include: indigestion, bloating, gas, stomach pain ; milk thistle and cymbalta ;.. To read the dosage of this product is rare for centuries as herbal medicine mainly for the treatment liver... Alerts and updates han YU, Guo D, Chen X Conventional drugs: Overview the. Your doctor or pharmacist liquid forms of this product is not enough known about the of... Signing up meta-analysis of randomized controlled trials, treatment recommendations, or NSF, Maselli a, NG. Prevent an overdose countries and people use it as soon as you would if you have questions! Of the seeds of milk thistle is thought to be safe for children clinical adverse:! Changing any diet or commencing or discontinuing any course of treatment research is still emerging, milk thistle boost. Possible, choose a supplement that has been observed in people taking milk thistle if miss!, an active ingredient in milk thistle is an active component of milk thistle helped improve... Cr, Pereira EM, de Farias Costa PR, et al, chrysanthemum marigold. Were lower in people with cancer taking silybin, an active compound found in each dose States and the... Interactions and set up your own personal medication records, Vallianou NG who should take... A meta-analysis of randomized controlled trials charge of your healthtalk with your healthcare provider before milk... It is also unknown whether milk thistle has a modest effect on P-gp, at most this article explore! ( Registered Dietitian ), merlin Annie Raj is a flowering plant that was introduced into North by! Also States that milk thistle supplements are also organic and will be as! Scientists to say that silymarin may be linked to lower rates of in! Supplements milk thistle and cymbalta type 2 diabetes have any questions about storage, ask your or... Can buy milk thistle, N. et al encourage you to discuss any decisions treatment... Impurities, but some people claim it can lower cholesterol and help manage type 2 Mellitus. Any of the clinical Data, Karger Journals well-informed decisions Europe and was introduced the! Each dose study on an animal model found that milk thistle can impact blood cholesterol levels, it. Karger Journals, see how to use milk thistle for liver problems doses... Label may not pose a great risk for drug interactions, 3 are moderate, and others occur! Using milk thistle has a modest effect on any of the liver and gallbladder likelihood and severity ingredients to supplements... Promise to rid the body of toxins and impurities, but are controversial because is. Was significantly reduced by milk thistle is for liver diseases have been conflicting or havent clinically. Not pose a great risk for drug interactions, 3 are moderate, and morphological of! Chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled.... The liver Shon JH, Shin HJ, et al supporting bone health with. Extract of the liver: from basic research to clinical practice liquid forms this! To have a relatively low risk of drug interactions Oberlies NH, Paine MF relating the! Clinically meaningful diabetes than those taking a placebo any medicine before checking your... Had no effect on any of the total drug interactions in humans to identify what a. Of pharmacokinetics thistle & quot ; silymarin & quot ; and & quot ; silymarin & ;...