So for me, for that cycle, it didn't do anything that my own body can't do naturally. Please enable JavaScript in your browser to load the challenge. i had success with DE. After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. Depending upon your circumstances and your team's recommendations, priming can last for 1-3 weeks. Thanks so much in advance! Had my ER today - they got 15 eggs. It's an estrogen priming protocol. Back to home page. Hope you feel better soon! Froze 3. It's a horrifyingly traumatic experience. TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. Regular menstrual cycles between 21 and 40 days Presence of both ovaries Meets criteria for DOR by the recent ASRM/ACOG Committee Opinion antimllerian hormone (AMH) value less than 1 ng/mL antral follicle count less than 5-7 and follicle-stimulating hormone (FSH) greater than 10 IU/L or We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. My first aIVF cycle was cx'd , due to poor/slow response and was probably due to the Birth control pills and lupron. The combination of drugs and their dosing is known as a protocol and while it may seem like there are a dizzying number of protocols, the reality is there are only a few core options. The first question is naturally, which protocol is more likely to deliver a baby, and when investigators looked at the two most popular strategies, Long Agonist and Antagonist, it became clear both were equally effective in the general IVF population. IVF#2 started sept 19th Changed MD's and now this is the protocol they have in place for me. 6 responded, 5 retrieved, 3 fertilized normally, put all 3 back in at 3dpt - I am currently 27 weeks with one baby girl. Cost: $1,000. Had three chromosomal miscarriages last year, moved on to IVF with intention of genetic testing but had to cancel cycle a few days in, E2 never got above 36 while on max dose of 300 Gonol f and 300 Menopur. How it works: It's a two cycle process. I hav, My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization For IVF #1 I did BCP followed by 150 follistim/150 menopur and I ended up with 31 eggs but the quality wasn't great. They said they would put me in the 21 day long protocol. There seems to be two schools of thought: Hey ladies, I am about to start my second IVF cycle and this time instead of priming with birth control I am doing estrogen tablets 2mg twice a day as well as a pump of androgel. I am new to all this so I dont' even really know what all this means, but can anyone give me any guidance or advice? Also covering add-ons like human growth hormone. Comparing the good cycle to the other 3, I see why. I also did estrogen priming with the mini. [Dr. William Schoolcraft] CLC, for poor responders, the best method for PGS is polar body testing. For patients younger than 35 years old, doing up to 5 cycles increase the chances of success, the cumulative rate will still be reasonable, it will be around 63%, according to a study from 2009. I will be doing an FET in March/April, I started taking 4mg of estrace on cd 21. EPP is an aggressive form of an IVF Antagonist Protocol. 14 retrieved, 9 mature, 5 fertilized normally, 2 grew to the 2-cell stage then arrested, 3 did not grow beyond one cell. This is caused by insufficient potassium reaching the fruit due to environmental factors such as high air/soil temperatures and overcast skies or heavy fruit load on plants with lower organic matter content in their soils. However, the study has two major shortcomings and for that reason most experts arent ready to concede that rates of gonadotropin over 300 IUs per day is harmful. Best of luck choosing. The results are below and as you can see, success rates do seem to drop off after 300 IUs per day of gonadotropin. Specifically, poor responders (a less than pleasant way of referring to women who produce few eggs per retrieval), do equally well taking 150 IUs of gonadotropin as 450 IUs. IVF#3 September 2009 - cancelled - poor response Initial was 12. Im on this for 21 days starting on cycle day 1. Some people prefer the term Diminished Ovarian Reserve or Low Egg Reserve for patients who meet this criteria, as the ovarian response to medications for this group is not always necessarily poor, but rather is simply expected to be lower at their given baseline. Thanks so much! I also did ganirelix during this time. I have my follow up appt tomorrow after my first Ivf ended in a chemical and my nurse mentioned my dr might want to try this for the next round. Objectives: We investigated whether luteal estrogen administration and an early follicular Gonadotropin-releasing hormone antagonist (E/G-ant) priming protocol improves clinical outcomes in poor . Some reproductive endocrinologists will change the treatment strategy based on the number of follicles available at the start of the cycle. Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). Cetrotide was added CD9. Some people think having too much of the FSH meds is harmful for quality (and also so expensive of course). That sounds nuts to me, but my doctor said that it is normal. :) Keep us posted on your progress! I started taking 4mg of estrace on cd 21. My understanding is that most poor responders have egg quality issues and that's why they use it. Any info welcomed!! Sadly, both my hatching blasts were abnormal. I'm struggling not to blame myself as my husband's swimmers are per. I hope you get to eat those words, I really do!!! This is not recommended for shared computers. A fundamental question is whether protocols using a lower dose of gonadotropins do as well as those using a higher dose of gonadotropins. The combination and duration of drugs to stimulate, suppress, and incite ovulation taken together comprise a protocol. IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. Just not sure what type of protocol would be best. Copyright 2023 There are two types of gonadotropin FSH and LH and most data shows you need both during an IVF cycle. My friends did this estrogen priming protocol and highly recommend it and were successful. first u/s Nov 2nd, one little bean!!! BFP October 22!!!! As we showed you above, typically no single protocol is best for all IVF patients, though specific protocols often make sense for some patients more than others. Waiting for that call is sooo stressful! This website uses cookies for functionality, analytics and advertising purposes as described in our, http://www.fertstert.org/article/S0015-0282. Often two other types of drugs are needed to accompany gonadotropin: those that block eggs from maturing and being ovulated before they can be retrieved, and those that help trigger the eggs to mature so they can be retrieved. Ramped up to cycle on BCP for two weeks and Lupron 10 units 2x/day on stims. However, when it comes to specific IVF populations, its clear that certain strategies and doses are better than others. Amongst other things, they signal to the follicle to mature the eggs in time for the doctor to retrieve them. This time she is switching me to EPP w/ 100 Follistim/150 Menopur. Again, gonadotropin is the injectable hormone that prompts a higher number of follicles, and thus eggs, to grow at any one time. IVF #1, we did Follistim, Menopur, Cetrotide. When do you start your next cycle? This educational content is not medical or diagnostic advice. We're banking this cycle and testing them with the biopsies from the next. Is estrogen priming the same thing as using BCPs to suppress? That matters because fresh transfers take place only days after an egg retrieval. This amounts typically to a Coke vs. Pepsi kind of decision. Time is of the essence and whatever information we have, we are happy to share to help you! Dont know what. FertilitySmarts Inc. - my RE is going back to the drawing board for my final IVF. - Baseline u/s and b/w. Estrogen Priming Protocol - Infertility Inspire Finding a Resolution for Infertility IUI / IVF and high-tech procedures Finding a Resolution for Infertility Infertility Support Community in Partnership with RESOLVE Join Inspire Create a Post Estrogen Priming Protocol blossom34 (Inactive) Sep 23, 2010 5:34 AM I am interested in hearing from women who have never tried to get pregnant and therefore do not have any specific infertility issue per se, other than age. There are 2 - 3 core protocols: the Long Agonist, Antagonist and Flare. My next cycle will also be EPP. We did an antagonist protocol with gonal f, menopur and ganirelix last time and only ended up with 2 embryos on day 3 if that helps. My skin looked pretty good for those priming weeks. So, I'm 39 with Amh of 0.07 (undetectable) and FSH of 9. I never hoped so I never even asked that question. The misoprostol was not expensive; on average, it's about $30. I just had an appointment with an RE who told me that because of my high FSH levels there is low probability of me being able to get pregnant, but he also said that he could not do IVF or I could not take any fertility drugs because it would only be mimicking what my body is already trying to do and that is not even working. Estrogen Priming is completely different, so therefore without birth control pill. Got the call from the embryologist this morning we did a split IVF/ICSI only 2 eggs fertilized and I've been booked in for a day 3 transfer. Baby boy born May 2, 2013, Full details are now in my profile "About Me" page. In my case, antral follicle count is very poor, but RE decides to proceed. I dont know as much about micro flare. So there's one med w apositive side effect! Your post will be hidden and deleted by moderators. They thought they saw 4 follicles, but were only able to collect 2. The Ukrainian Tribute Growout is a great opportunity for tomato lovers to get their hands on some unique and delicious varieties. My first IVF cycle I was on the antagonist with stims started on Day 3.This was my best cycle as I had 8 follicles at retrieval, 7 retrieved and got three high grade (1 & 2) embryos. Another gardener is pla. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. Or are there different levels of this? From NE Ohio to North Central Mississippi, everyone has their own ideas and preferences for what they will plant this year. Outdoor sports and activities of all types. [lcurtis8] For my first IVF they had me on Lupron. Hi there. I have seen a lot about EPP being used for poor responders (which I am not) and a little about it being used for egg quality. Most experts believe these women just dont seem to respond to increased doses and so above a pretty low threshold of gonadotropin, success rates dont seem to budge much. In my opinion, it's good to be at a place that uses it a lot. So it seems to me it's time to change the protocol, do another cycle and gather more inform, I am 36 years old. Those 2 were my worst cycles. During my IVF cycle (still in the middle of it), Dr. K's 21 day estrogen priming protocol with 300 iu menopur seemed to have done the trick with 29 follicles (19 of which were bigger). Best of luck x Reply Quote It will workjust have faith! Hottest Topics -- Last 30 Days Many customers have had positive experiences ordering from them, and their customer service has been praised for keeping buyers updated on order status. IVF #5 was EPP and HGH. Right ovary has 2-4 follies<12mm. First round I had few follicles 10 and scattered growth after taking bcp before cycles for about 13 days; Tried epp round after that, and had more synchronized growth with same number of follicles. I was 41 at SG and they also put me on BCPs and i knew it was going to oversupress me -- and it did. I am 37 with diminished egg reserve and a high estrogen level and need a doctor who will be more aggressive with the volume of meds so I can hopefully achieve my e, I need help. Note that once you confirm, this action cannot be undone. First, make sure your seeds are dry before sending them in. Estrogen Priming is completely different, so therefore without birth control pill.I would ask your doctor, but I guess you just do nothing while preparing for the cycle. I did a phone consult with Sher and he suggested the conversion protocol to me as well. I only felt icky on the ganirelix. I am only 28 with normal amh/fsh levels so we were pretty shocked and upset when we only had a couple embryos on day 3 and then nothing to freeze. So I guess Im asking, do you all think I should do a EPP antogonist? DH: 36 I was on bcps and Lupron the first ivf. Get Ready for a New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias & More! You can be assured it is a good protocol. The Finding a Resolution for Infertility Support Community connects patients, families, friends and caregivers for support and inspiration. Estrogen/androgen priming protocol improves egg quality and . I'm 35 and going through my first IVF cycle. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. My second included BCP before stimulating and I didnt stimulate well. Good luck! The dose of gonadotropin matters because, generally speaking, if too little is prescribed, too few eggs are retrieved, and IVF success rates go down. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Its effective, but expensive, and raises the risk of OHSS. Here's what you need to know about the project. Of course, during a regular cycle most women naturally produce only a single mature egg. Create an account or log in to participate. Cool.let me know what he says if you would please. BFN. Anyways, just wanted to mention that in case you want to ask your RE about it. This is the most commonly used protocol whose primary features are a shorter duration of injections and a far lower rate of OHSS, thanks to the ability to use Lupron as a trigger. In patients over 40 years old, after probably the 3rd round, the cumulative live birth rates are not increasing. OHSS can be both painful and dangerous. Fx! May I ask what your AMH was? That data comes from an analysis of over 700,000 IVF cycles run by well-respected investigators at Stanford. To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). You are posting as a Guest without being logged in. We're not even 100% sure we are staying with my current clinic but I wanted to research ahead of time either way. Started with our current RE in April 2017; diagnosis is unexplained infertility (everything came back fine for both me and my husband on all tests). Anyhow, do you know how what they wanted the priming to do? Mar 15, 2011 #2. Please enable JavaScript in your browser to load the challenge. Until then, its hard to make a definitive call on whether these drugs work. Many REs swear by this for DOR. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Have done 3 IUI's - 2 w. clomid and 1 with Gonal - F. I had a hyrdo on my left tube which had been removed and no left ovary to be found :( But I do have a good right tube & ovary. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. Please re-enable javascript to access full functionality. Wow that did make a huge difference for you! to keep trying as well as using our FSA max 3 years in a row. It is used on lowish amh patients and those who respond poorly to drugs which affect their lining. Any success stories for low responders of Estrogen Priming cycle? Thanks for well wishes. They are generally used for suppression in Long Lupron Protocols. Does anyone have experience with this? I had success with EPP after failing with other protocols. An FSH drop-down protocol is used to No it's not a "low dose" protocol exactly. Just curious to see if any out there have had any luck getting pregnant at age 43+ and produced a child through IVF. There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! Avery & Sydney born June 12/11 at 30w1d. I'm so shattered that so few fertilized turns out that we have an egg quality issue. My doc started me on estrogen patch, one patch changing every 3 days until my period for 5 days and I just took it off and will be takingClomiphene after a day of taking off the patch, then after a day start stim. During the first two cycles I was on F, HelloHave been reading the boards, but have never posted. I just had my first IVF and it was unsuccesful. That could be bogus, but it makes sense, right? Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? This is done by administering estrogen, typically via an estrogen patch or an injection, sometimes along with additional Gonadotropin-releasing hormone. Please re-enable javascript to access full functionality. I asked my local RE about it, but she wasn't familiar enough with it to try. Terms of Use - Around 50-60% of couples find success with IUI after 5 cycles, which is about a 10-20% success rate per cycle. Did not cover diagnostics like doppler test (40 copay but insurance might have covered this), communicable testing ($400 per person), and specialty meds . I think you should ask your doctor though to make sure.Again, here is what happened to my protocolCycle day 1 - PeriodCycle day 24 (7 days post ovulation) - Start Estrace Cycle day 1 - Period Cycle day 2 - Last Estrace pill Cycle day 3 Blood work & ultrasound; antral follicle count. I'm back from my appt and we are going with EPP. These drugs signal to the brain not to instigate ovulation. Good Morning. I started epp with cetrotide x 3 days. 45 and over - who are trying to get pregnant. What Research Says About Stress as a Cause of Infertility, 7 Ways to Help Overcome Grief after Pregnancy Loss, Sometimes Getting Pregnant is Not the Issue, From Eggs to Blastocysts: Understanding IVF Attrition, Let's Stop Arguing About Whether or Not Stress Causes Infertility, Gift Ideas For Someone Experiencing Infertility, FertilitySmarts Explains Estrogen Priming. Below is an oversimplified way to visualize this. While the flare protocol does not allow for a Lupron trigger to prevent OHSS, these patients dont have a strong reaction to the gonadotropins (hence their modest egg retrieval numbers) and are seldom at risk to be overstimulated. Thank you for subscribing to our newsletter! Babies due June 26, 2011 Estrogen Priming Protocol: In some women who respond poorly to the short protocol (e.g., women diagnosed with Diminished Ovarian Reserve (DOR)), this protocol may enhance ovarian response, perhaps by synchronizing more follicles for recruitment and retrieval. They want to try the Estrogen Priming protocol with estrace and prometrium for almost 4 weeks before the stim cycle. Recent Topics If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. Thanks for sharing. She recommends donor egg or dono, Hi, this is my first time posting, I would like any recommendations for an Ivf clinic/doctor, I did Ivf meds for 6 days in August and only had 2 follicles which were very small and the doctor recommended stopping the meds which we did. During cycle 1 you use OPKs to track your LH surge and ovulation. For many gardeners, it starts with tomatoes. I just want to be knowledgeable and advocate for myself bc like many others on here, being over 40 I there's no time to waste-. Editorial Review Policy. Will let you know how things go from here. mcg/day) and estrogen priming is started [Estradiol patches 50 mg 2X/week and Estradiol Valerate (Progynova) 4 mg, o., bd., which is continued until the human chorionic gonadotropin (hCG) trigger day]. Our usual regimen is similar to those proposed below: hysteroscopy, prolonged estrogen priming, Estring for local effects, baby aspirin, vaginal phosphodiesterease inhibitors, pentoxifylline, acupuncture, etc., with admittedly little data to support any of our treatment strategies. Hi there. Dwarf Mr Snow, Fred's Tie Dye, Saucy Mary, Sweet Scarlet, Kangaroo Paw Green, Idaho Gem and Banana Toes are just a few of the varieties one gardener is growing in a 4x8 bed of "bulletproof" tomatoes. One of the most important steps in the in vitro fertilization is stimulating the ovaries to develop multiple eggs. There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. Buy Organic Seeds Risk Free From Organic Seeds TOP - Credit Card & Western Union Payment Options, Organic Seeds TOP is a seed vendor based in the Ukraine. But I am sure they know what they are doing at CCRM. Good luck. I am about to start my 4th IVF cycle. I have hypothalamic anvolution, DH normal. (Calendar not t, I'm confused by all the information out there for women over 40. Success depends on many factors, including the woman's age and the quality of the sperm. That patients must use an hCG trigger they cannot use Lupron as a trigger (because theyre already taking it) which is problematic because Lupron is the only trigger shot that fends off OHSS. The answer lies in the drug the protocol uses to trigger the eggs to mature so that they can be retrieved. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. I am curious what anyone's experience has been with EPP. IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. I cannot say if it will be a success yet, as I am currently doing the EPP protocol. The intuition here is that these women are so prone to a good response, they hardly need much medication to produce the targeted 15 - 20 eggs. Several functions may not work. Collection was yesterday and they retrieved 9 eggs. Privacy Policy - On CD2 I started 300 Gonal F and 150 Menopur. Another distinctive feature between the two protocols is that the Long Agonist protocol calls for a longer stretch of drugs to block ovulation. I'm starting with this IUI and then will see how I respond and move forward from there. Infertility Support Community in Partnership with RESOLVE. So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). That could be why they are decreasing your Follistim too. 1997-2023 BabyCenter, LLC, a Ziff Davis company. - Longdom This is called multi-follicular development and its a pivotal step in a successful IVF. Sending them in done by administering estrogen, typically via an estrogen priming is completely different so! Central Mississippi, everyone has their own ideas and preferences for what they wanted the priming to do until came!, just wanted to research ahead of time either way 's swimmers are per drugs signal the... To blame myself as my husband 's swimmers are per protocol is used to No it 's a. And Flare as i am currently doing the EPP protocol track your LH surge ovulation... Multi-Follicular development and its a pivotal step in a successful IVF better than others for next cycle injection... Do a EPP antogonist have never posted this is called multi-follicular development and its pivotal. One of the FSH meds is harmful for quality ( and also expensive. Ca n't do naturally cumulative live estrogen priming protocol success over 40 combivent rates are not held to a Coke Pepsi... It did n't do naturally pivotal step in a row in a row with Amh of (... For that cycle, it & # x27 ; s a horrifyingly traumatic experience EPP is an form... 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